The creation of creating heart tissue from induced pluripotent stem cells (iPS) has generated interest in a wide range of biomedical research segments that include regenerative cardiovascular research, with it recently being used for personalized cardiac therapy and disease modeling.
The use of induced pluripotent stem cells cell-derived heart tissue to screen for potential therapeutic compounds enables a personalized approach to patient healthcare. It is for these and many more reasons that precision-cut tissue slices represent an in vitro model that is known to mimic closely the multi-cellular complexity, extra-cellular interactions, structural and functional features of the whole organ. These slices retain the functional heterogeneity and the biochemical capacity allowing for the assessment of total metabolism and potential toxicity of a compound under conditions most similar to the in vivo situation.
By doing this, higher level of biological organization which may better reflect the response of the target organ and maintenance of functional heterogeneity and biochemical capacity. It is also useful in the preservation of Phase I and Phase II drug metabolism reactions and applicability of the tissue slice system to donated, non-transplantable human tissue and higher level of biological organization which may better reflect the response of the target organ. In addition to that, the use of human tissue slices or tissue cores in the context of organ-specific toxicity, drug biotransformation, and environmental contaminant studies is more relevant for predicting what may be seen in human beings.
In this respect, Vitron has been a pioneer in the multi-cellular and extracellular matrix composition of tissue slices that reflect the biologically relevant structural and functional features of in vivo tissue to facilitate and advance mechanistic investigations. It is one of the most eminent industry experts in drug candidate selection, identifying sensitive biomarkers of side effects, and augmenting the extrapolation and translation of animal and human in vitro results into clinical applications and predictions.